Biochemical and Phenotypic Abnormalities in Kynurenine Aminotransferase II-Deficient Mice

Kynurenic acid (KYNA) can act as an endogenous modulator of excitatory neurotransmission and has been implicated in the pathogenesis of several neurological and psychiatric diseases. To evaluate its role in the brain, we disrupted the murine gene for kynurenine aminotransferase II (KAT II), the prin...

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Bibliografiska uppgifter
Huvudupphovsmän: Yu, Ping, Di Prospero, Nicholas A., Sapko, Michael T., Cai, Tao, Chen, Amy, Melendez-Ferro, Miguel, Du, Fu, Whetsell, William O., Guidetti, Paolo, Schwarcz, Robert, Tagle, Danilo A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC479723/
https://ncbi.nlm.nih.gov/pubmed/15282294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.6919-6930.2004
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