Biochemical and Phenotypic Abnormalities in Kynurenine Aminotransferase II-Deficient Mice

Kynurenic acid (KYNA) can act as an endogenous modulator of excitatory neurotransmission and has been implicated in the pathogenesis of several neurological and psychiatric diseases. To evaluate its role in the brain, we disrupted the murine gene for kynurenine aminotransferase II (KAT II), the prin...

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Bibliografiske detaljer
Main Authors: Yu, Ping, Di Prospero, Nicholas A., Sapko, Michael T., Cai, Tao, Chen, Amy, Melendez-Ferro, Miguel, Du, Fu, Whetsell, William O., Guidetti, Paolo, Schwarcz, Robert, Tagle, Danilo A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC479723/
https://ncbi.nlm.nih.gov/pubmed/15282294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.6919-6930.2004
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