Biochemical and Phenotypic Abnormalities in Kynurenine Aminotransferase II-Deficient Mice

Kynurenic acid (KYNA) can act as an endogenous modulator of excitatory neurotransmission and has been implicated in the pathogenesis of several neurological and psychiatric diseases. To evaluate its role in the brain, we disrupted the murine gene for kynurenine aminotransferase II (KAT II), the prin...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Yu, Ping, Di Prospero, Nicholas A., Sapko, Michael T., Cai, Tao, Chen, Amy, Melendez-Ferro, Miguel, Du, Fu, Whetsell, William O., Guidetti, Paolo, Schwarcz, Robert, Tagle, Danilo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15282294/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.16.6919-6930.2004
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