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Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important tran...
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| Pubblicato in: | Genome Med |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4797182/ https://ncbi.nlm.nih.gov/pubmed/26987311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0286-z |
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