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Optimization of DNA polymerase mutation rates during bacterial evolution
Mutation rate is an important determinant of evolvability. The optimal mutation rate for different organisms during evolution has been modeled in silico and tested in vivo, predominantly through pairwise comparisons. To characterize the fitness landscape across a broad range of mutation rates, we ge...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824296/ https://ncbi.nlm.nih.gov/pubmed/20080608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912451107 |
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