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The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion
To investigate the role of promoters in regulating variable gene rearrangement and allelic exclusion, we constructed mutant mice in which a 1.2-kb region of the Vβ13 promoter was either deleted (P13(−/−)) or replaced with the simian virus 40 minimal promoter plus five copies of Gal4 DNA sequences (P...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC479718/ https://ncbi.nlm.nih.gov/pubmed/15282302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7015-7023.2004 |
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