Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.
Formation of a complete immunoglobulin heavy-chain transcription unit involves the ordered rearrangement of variable (V), diversity (D), and joining (J) region gene segments. In antibody-producing cells, this process is regulated such that only one of two antibody genes is expressed. Experiments wit...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1992
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1372438/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2205 |
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