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Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

Formation of a complete immunoglobulin heavy-chain transcription unit involves the ordered rearrangement of variable (V), diversity (D), and joining (J) region gene segments. In antibody-producing cells, this process is regulated such that only one of two antibody genes is expressed. Experiments wit...

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Bibliografiska uppgifter
Huvudupphovsmän: Costa, T E, Suh, H, Nussenzweig, M C
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC48625/
https://ncbi.nlm.nih.gov/pubmed/1372438
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