Rat growth hormone gene introns stimulate nucleosome alignment in vitro and in transgenic mice.
Average hepatic expression (mRNA per cell per gene) of a metallothionein-rat growth hormone (rGH) gene with its natural introns was about 15-fold higher than an intronless version when tested in transgenic mice. We examined the idea that intron removal leads to an alteration in chromatin structure t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7724 |
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