DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.

Hepatocyte-directed production of urokinase-type plasminogen activator (uPA) in transgenic mice is hepatotoxic. Infrequently, hepatocytes arise that do not express uPA, due to physical loss of transgene DNA, and these cells clonally repopulate the entire liver within 3 months of birth. Surprisingly,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Sandgren, E P, Palmiter, R D, Heckel, J L, Brinster, R L, Degen, J L
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1992
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC50584/
https://ncbi.nlm.nih.gov/pubmed/1454842
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