DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.

Hepatocyte-directed production of urokinase-type plasminogen activator (uPA) in transgenic mice is hepatotoxic. Infrequently, hepatocytes arise that do not express uPA, due to physical loss of transgene DNA, and these cells clonally repopulate the entire liver within 3 months of birth. Surprisingly,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sandgren, E P, Palmiter, R D, Heckel, J L, Brinster, R L, Degen, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50584/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1454842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.23.11523
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