DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.

Hepatocyte-directed production of urokinase-type plasminogen activator (uPA) in transgenic mice is hepatotoxic. Infrequently, hepatocytes arise that do not express uPA, due to physical loss of transgene DNA, and these cells clonally repopulate the entire liver within 3 months of birth. Surprisingly,...

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Detaylı Bibliyografya
Asıl Yazarlar: Sandgren, E P, Palmiter, R D, Heckel, J L, Brinster, R L, Degen, J L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1992
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC50584/
https://ncbi.nlm.nih.gov/pubmed/1454842
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