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The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination

The precise function of cis elements in regulating V(D)J recombination is still controversial. Here, we determined the effect of inactivation of the TCRβ enhancer (Eβ) on cleavage and rearrangement of Dβ1, Dβ2, Jβ1, and Jβ2 gene segments in CD4(-)CD8(-) [double-negative (DN)] and CD4(+)CD8(+) [doubl...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ryu, Chun Jeih, Haines, Brian B., Draganov, Dobrin D., Kang, Yun Hee, Whitehurst, Charles E., Schmidt, Tara, Hong, Hyo Jeong, Chen, Jianzhu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14593206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2235807100
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