The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination

The precise function of cis elements in regulating V(D)J recombination is still controversial. Here, we determined the effect of inactivation of the TCRβ enhancer (Eβ) on cleavage and rearrangement of Dβ1, Dβ2, Jβ1, and Jβ2 gene segments in CD4(-)CD8(-) [double-negative (DN)] and CD4(+)CD8(+) [doubl...

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Main Authors: Ryu, Chun Jeih, Haines, Brian B., Draganov, Dobrin D., Kang, Yun Hee, Whitehurst, Charles E., Schmidt, Tara, Hong, Hyo Jeong, Chen, Jianzhu
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC263837/
https://ncbi.nlm.nih.gov/pubmed/14593206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235807100
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