The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination

The precise function of cis elements in regulating V(D)J recombination is still controversial. Here, we determined the effect of inactivation of the TCRβ enhancer (Eβ) on cleavage and rearrangement of Dβ1, Dβ2, Jβ1, and Jβ2 gene segments in CD4(-)CD8(-) [double-negative (DN)] and CD4(+)CD8(+) [doubl...

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Detaylı Bibliyografya
Asıl Yazarlar: Ryu, Chun Jeih, Haines, Brian B., Draganov, Dobrin D., Kang, Yun Hee, Whitehurst, Charles E., Schmidt, Tara, Hong, Hyo Jeong, Chen, Jianzhu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC263837/
https://ncbi.nlm.nih.gov/pubmed/14593206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235807100
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