The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination

The precise function of cis elements in regulating V(D)J recombination is still controversial. Here, we determined the effect of inactivation of the TCRβ enhancer (Eβ) on cleavage and rearrangement of Dβ1, Dβ2, Jβ1, and Jβ2 gene segments in CD4(-)CD8(-) [double-negative (DN)] and CD4(+)CD8(+) [doubl...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ryu, Chun Jeih, Haines, Brian B., Draganov, Dobrin D., Kang, Yun Hee, Whitehurst, Charles E., Schmidt, Tara, Hong, Hyo Jeong, Chen, Jianzhu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14593206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2235807100
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!