The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion

To investigate the role of promoters in regulating variable gene rearrangement and allelic exclusion, we constructed mutant mice in which a 1.2-kb region of the Vβ13 promoter was either deleted (P13(−/−)) or replaced with the simian virus 40 minimal promoter plus five copies of Gal4 DNA sequences (P...

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Detalhes bibliográficos
Main Authors: Ryu, Chun Jeih, Haines, Brian B., Lee, Hye Ran, Kang, Yun Hee, Draganov, Dobrin D., Lee, Minhui, Whitehurst, Charles E., Hong, Hyo Jeong, Chen, Jianzhu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC479718/
https://ncbi.nlm.nih.gov/pubmed/15282302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7015-7023.2004
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