The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion

To investigate the role of promoters in regulating variable gene rearrangement and allelic exclusion, we constructed mutant mice in which a 1.2-kb region of the Vβ13 promoter was either deleted (P13(−/−)) or replaced with the simian virus 40 minimal promoter plus five copies of Gal4 DNA sequences (P...

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Bibliografische gegevens
Hoofdauteurs: Ryu, Chun Jeih, Haines, Brian B., Lee, Hye Ran, Kang, Yun Hee, Draganov, Dobrin D., Lee, Minhui, Whitehurst, Charles E., Hong, Hyo Jeong, Chen, Jianzhu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2004
Onderwerpen:
DNA Dynamics and Chromosome Structure
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC479718/
https://ncbi.nlm.nih.gov/pubmed/15282302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7015-7023.2004
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