Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation

Platelets are essential for hemostasis, and thrombocytopenia is a major clinical problem. Megakaryocytes (MKs) generate platelets by extending long processes, proplatelets, into sinusoidal blood vessels. However, very little is known about what regulates proplatelet formation. To uncover which prote...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Machlus, Kellie R., Wu, Stephen K., Stumpo, Deborah J., Soussou, Thomas S., Paul, David S., Campbell, Robert A., Kalwa, Hermann, Michel, Thomas, Bergmeier, Wolfgang, Weyrich, Andrew S., Blackshear, Perry J., Hartwig, John H., Italiano, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797023/
https://ncbi.nlm.nih.gov/pubmed/26744461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-08-663146
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