TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction

TRIM5α is an interferon-inducible retroviral restriction factor that prevents infection by inducing the abortive disassembly of capsid cores recognized by its C-terminal PRY/SPRY domain. The mechanism by which TRIM5α mediates the disassembly of viral cores is poorly understood. Previous studies demo...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Imam, Sabrina, Talley, Sarah, Nelson, Rachel S., Dharan, Adarsh, O'Connor, Christopher, Hope, Thomas J., Campbell, Edward M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794682/
https://ncbi.nlm.nih.gov/pubmed/26764007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03033-15
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