K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α

TRIM5α is an antiviral restriction factor that inhibits retroviral infection in a species-specific fashion. TRIM5α binds to and forms assemblies around the retroviral capsid. Following binding, poorly understood, ubiquitin-dependent events lead to the disassembly of the viral core, prior to the accu...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Imam, Sabrina, Kömürlü, Sevnur, Mattick, Jessica, Selyutina, Anastasia, Talley, Sarah, Eddins, Amani, Diaz-Griffero, Felipe, Campbell, Edward M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600202/
https://ncbi.nlm.nih.gov/pubmed/31068426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00558-19
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