TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization

Rhesus macaque TRIM5α (rhTRIM5α) is a retroviral restriction factor that inhibits HIV-1 infection. Previous studies have revealed that TRIM5α restriction occurs via a two-step process. The first step is restriction factor binding, which is sufficient to inhibit infection. The second step, which is s...

Full description

Saved in:
Bibliographic Details
Published in:J Virol
Main Authors: Campbell, Edward M., Weingart, Jared, Sette, Paola, Opp, Silvana, Sastri, Jaya, O'Connor, Sarah K., Talley, Sarah, Diaz-Griffero, Felipe, Hirsch, Vanessa, Bouamr, Fadila
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733990/
https://ncbi.nlm.nih.gov/pubmed/26676782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01948-15
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items