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Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding
BACKGROUND: HIV-1 relies on the host ESCRTs for release from cells. HIV-1 Gag engages ESCRTs by directly binding TSG101 or Alix. ESCRTs also sort ubiquitinated membrane proteins through endosomes to facilitate their lysosomal degradation. The ability of ESCRTs to recognize and process ubiquitinated...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3751857/ https://ncbi.nlm.nih.gov/pubmed/23895345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-79 |
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