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Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding

BACKGROUND: HIV-1 relies on the host ESCRTs for release from cells. HIV-1 Gag engages ESCRTs by directly binding TSG101 or Alix. ESCRTs also sort ubiquitinated membrane proteins through endosomes to facilitate their lysosomal degradation. The ability of ESCRTs to recognize and process ubiquitinated...

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Bibliografski detalji
Glavni autori: Sette, Paola, Nagashima, Kunio, Piper, Robert C, Bouamr, Fadila
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751857/
https://ncbi.nlm.nih.gov/pubmed/23895345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-79
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