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Binding of the Rhesus TRIM5α PRYSPRY Domain to Capsid is Necessary but not Sufficient for HIV-1 Restriction

The PRYSPRY domain of TRIM5α provides specificity and the capsid recognition motif to retroviral restriction. Restriction of HIV-1 by rhesus TRIM5α (TRIM5α(rh)) has been correlated to its ability to bind to the HIV-1 core, suggesting that capsid binding is required for restriction. This work explore...

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Autori principali: Yang, Yang, Branderiz-Nuñez, Alberto, Fricke, Thomas, Ivanov, Dmitri, Sarnak, Zoe, Diaz-Griffero, Felipe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900861/
https://ncbi.nlm.nih.gov/pubmed/24314652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.10.012
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