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Binding of the Rhesus TRIM5α PRYSPRY Domain to Capsid is Necessary but not Sufficient for HIV-1 Restriction
The PRYSPRY domain of TRIM5α provides specificity and the capsid recognition motif to retroviral restriction. Restriction of HIV-1 by rhesus TRIM5α (TRIM5α(rh)) has been correlated to its ability to bind to the HIV-1 core, suggesting that capsid binding is required for restriction. This work explore...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3900861/ https://ncbi.nlm.nih.gov/pubmed/24314652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.10.012 |
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