Targeting Calcium Signaling To Induce Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

Targeting epigenetic pathways is a promising approach for cancer therapy. Here, we report on the unexpected finding that targeting calcium signaling can reverse epigenetic silencing of tumor suppressor genes (TSGs). In a screen for drugs that reactivate silenced gene expression in colon cancer cells...

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Publicado no:Cancer Res
Main Authors: Raynal, Noël J.-M., Lee, Justin T., Wang, Youjun, Beaudry, Annie, Madireddi, Priyanka, Garriga, Judith, Malouf, Gabriel, Dumont, Sarah, Dettman, Elisha J., Gharibyan, Vazganush, Ahmed, Saira, Chung, Woonbok, Childers, Wayne E., Abou-Gharbia, Magid, Henry, Ryan A., Andrews, Andrew J., Jelinek, Jaroslav, Cui, Ying, Baylin, Stephen B., Gill, Donald L., Issa, Jean-Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794357/
https://ncbi.nlm.nih.gov/pubmed/26719529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2391
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