Epigenetic synergy between decitabine and platinum derivatives

BACKGROUND: Aberrant epigenetic silencing of tumor suppressor genes has been recognized as a driving force in cancer. Epigenetic drugs such as the DNA methylation inhibitor decitabine reactivate genes and are effective in myeloid leukemia, but resistance often develops and efficacy in solid tumors i...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Qin, Taichun, Si, Jiali, Raynal, Noël J-M, Wang, Xiaodan, Gharibyan, Vazganush, Ahmed, Saira, Hu, Xin, Jin, Chunlei, Lu, Yue, Shu, Jingmin, Estecio, Marcos RH, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567801/
https://ncbi.nlm.nih.gov/pubmed/26366234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0131-z
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