Epigenetic synergy between decitabine and platinum derivatives

BACKGROUND: Aberrant epigenetic silencing of tumor suppressor genes has been recognized as a driving force in cancer. Epigenetic drugs such as the DNA methylation inhibitor decitabine reactivate genes and are effective in myeloid leukemia, but resistance often develops and efficacy in solid tumors i...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Qin, Taichun, Si, Jiali, Raynal, Noël J-M, Wang, Xiaodan, Gharibyan, Vazganush, Ahmed, Saira, Hu, Xin, Jin, Chunlei, Lu, Yue, Shu, Jingmin, Estecio, Marcos RH, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567801/
https://ncbi.nlm.nih.gov/pubmed/26366234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0131-z
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