Epigenetic synergy between decitabine and platinum derivatives

BACKGROUND: Aberrant epigenetic silencing of tumor suppressor genes has been recognized as a driving force in cancer. Epigenetic drugs such as the DNA methylation inhibitor decitabine reactivate genes and are effective in myeloid leukemia, but resistance often develops and efficacy in solid tumors i...

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Опубликовано в: :Clin Epigenetics
Главные авторы: Qin, Taichun, Si, Jiali, Raynal, Noël J-M, Wang, Xiaodan, Gharibyan, Vazganush, Ahmed, Saira, Hu, Xin, Jin, Chunlei, Lu, Yue, Shu, Jingmin, Estecio, Marcos RH, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2015
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567801/
https://ncbi.nlm.nih.gov/pubmed/26366234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0131-z
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