Mechanisms of Resistance to Decitabine in the Myelodysplastic Syndrome

PURPOSE: The DNA methylation inhibitor 5-aza-2′-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown. Therefore, we investigated mechanisms of primary and secondary resistance...

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Bibliografiske detaljer
Main Authors: Qin, Taichun, Castoro, Ryan, El Ahdab, Samih, Jelinek, Jaroslav, Wang, Xiaodan, Si, Jiali, Shu, Jingmin, He, Rong, Zhang, Nianxiang, Chung, Woonbok, Kantarjian, Hagop M., Issa, Jean-Pierre J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157379/
https://ncbi.nlm.nih.gov/pubmed/21858090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023372
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