Mechanisms of Resistance to Decitabine in the Myelodysplastic Syndrome

PURPOSE: The DNA methylation inhibitor 5-aza-2′-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown. Therefore, we investigated mechanisms of primary and secondary resistance...

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Detalhes bibliográficos
Main Authors: Qin, Taichun, Castoro, Ryan, El Ahdab, Samih, Jelinek, Jaroslav, Wang, Xiaodan, Si, Jiali, Shu, Jingmin, He, Rong, Zhang, Nianxiang, Chung, Woonbok, Kantarjian, Hagop M., Issa, Jean-Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157379/
https://ncbi.nlm.nih.gov/pubmed/21858090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023372
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