RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors

PURPOSE: Tumor-infiltrating lymphocytes (TILs) in the residual disease (RD) of triple-negative breast cancers (TNBCs) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking. EXPERIMENT...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Loi, Sherene, Dushyanthen, Sathana, Beavis, Paul A, Salgado, Roberto, Denkert, Carsten, Savas, Peter, Combs, Susan, Rimm, David L., Giltnane, Jennifer M., Estrada, Monica V., Sánchez, Violeta, Sanders, Melinda E., Cook, Rebecca S., Pilkinton, Mark A., Mallal, Simon A., Wang, Kai, Miller, Vincent A., Stephens, Phil J., Yelensky, Roman, Doimi, Franco D., Gómez, Henry, Ryzhov, Sergey V., Darcy, Phillip K., Arteaga, Carlos L., Balko, Justin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794351/
https://ncbi.nlm.nih.gov/pubmed/26515496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1125
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