RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors

PURPOSE: Tumor-infiltrating lymphocytes (TILs) in the residual disease (RD) of triple-negative breast cancers (TNBCs) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking. EXPERIMENT...

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Publicado en:Clin Cancer Res
Autores principales: Loi, Sherene, Dushyanthen, Sathana, Beavis, Paul A, Salgado, Roberto, Denkert, Carsten, Savas, Peter, Combs, Susan, Rimm, David L., Giltnane, Jennifer M., Estrada, Monica V., Sánchez, Violeta, Sanders, Melinda E., Cook, Rebecca S., Pilkinton, Mark A., Mallal, Simon A., Wang, Kai, Miller, Vincent A., Stephens, Phil J., Yelensky, Roman, Doimi, Franco D., Gómez, Henry, Ryzhov, Sergey V., Darcy, Phillip K., Arteaga, Carlos L., Balko, Justin M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794351/
https://ncbi.nlm.nih.gov/pubmed/26515496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1125
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