RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors

PURPOSE: Tumor-infiltrating lymphocytes (TILs) in the residual disease (RD) of triple-negative breast cancers (TNBCs) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking. EXPERIMENT...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Loi, Sherene, Dushyanthen, Sathana, Beavis, Paul A, Salgado, Roberto, Denkert, Carsten, Savas, Peter, Combs, Susan, Rimm, David L., Giltnane, Jennifer M., Estrada, Monica V., Sánchez, Violeta, Sanders, Melinda E., Cook, Rebecca S., Pilkinton, Mark A., Mallal, Simon A., Wang, Kai, Miller, Vincent A., Stephens, Phil J., Yelensky, Roman, Doimi, Franco D., Gómez, Henry, Ryzhov, Sergey V., Darcy, Phillip K., Arteaga, Carlos L., Balko, Justin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794351/
https://ncbi.nlm.nih.gov/pubmed/26515496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1125
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker