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Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote re...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605577/ https://ncbi.nlm.nih.gov/pubmed/28928458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00728-9 |
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