RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors

PURPOSE: Tumor-infiltrating lymphocytes (TILs) in the residual disease (RD) of triple-negative breast cancers (TNBCs) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking. EXPERIMENT...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Clin Cancer Res
المؤلفون الرئيسيون: Loi, Sherene, Dushyanthen, Sathana, Beavis, Paul A, Salgado, Roberto, Denkert, Carsten, Savas, Peter, Combs, Susan, Rimm, David L., Giltnane, Jennifer M., Estrada, Monica V., Sánchez, Violeta, Sanders, Melinda E., Cook, Rebecca S., Pilkinton, Mark A., Mallal, Simon A., Wang, Kai, Miller, Vincent A., Stephens, Phil J., Yelensky, Roman, Doimi, Franco D., Gómez, Henry, Ryzhov, Sergey V., Darcy, Phillip K., Arteaga, Carlos L., Balko, Justin M.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2015
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794351/
https://ncbi.nlm.nih.gov/pubmed/26515496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1125
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