CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors

Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that recognize lipid ligands presented by monomorphic CD1d. Human iNKT T cell receptor (TCR) is largely composed of invariant Vα24 (Vα24i) TCRα chain and semi-variant Vβ11 TCRβ chain, where complementarity-determining region (CDR)...

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Bibliographic Details
Published in:J Autoimmun
Main Authors: Chamoto, Kenji, Guo, Tingxi, Imataki, Osamu, Tanaka, Makito, Nakatsugawa, Munehide, Ochi, Toshiki, Yamashita, Yuki, Saito, Akiko M., Saito, Toshiki I., Butler, Marcus O., Hirano, Naoto
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792736/
https://ncbi.nlm.nih.gov/pubmed/26748722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.12.005
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