MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells

The adenoviral gene E1a is known to enhance the antitumor effect of cisplatin, one of the cornerstones of the current cancer chemotherapy. Here we study the molecular basis of E1a mediated sensitivity to cisplatin in an experimental model of Non-small cell lung cancer. Our data show how E1a blocks t...

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Udgivet i:Oncotarget
Main Authors: Cimas, Francisco J., Callejas-Valera, Juan L., Pascual-Serra, Raquel, García-Cano, Jesus, Garcia-Gil, Elena, De la Cruz-Morcillo, Miguel, Ortega-Muelas, Marta, Serrano-Oviedo, Leticia, Gutkind, J. Silvio, Sánchez-Prieto, Ricardo
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
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Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792544/
https://ncbi.nlm.nih.gov/pubmed/26689986
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