Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion

OBJECTIVES: To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of several Mitogen Activated Protein Kinases in Renal...

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Publicado en:PLoS One
Main Authors: Serrano-Oviedo, Leticia, Ortega-Muelas, Marta, García-Cano, Jesús, Valero, María Ll., Cimas, Francisco J., Pascual-Serra, Raquel, Fernandez-Aroca, Diego M., Roche, Olga, Ruiz-Hidalgo, María J., Belandia, Borja, Giménez-Bachs, José M., Salinas, Antonio S., Sanchez-Prieto, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062059/
https://ncbi.nlm.nih.gov/pubmed/30048489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200878
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