Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion

OBJECTIVES: To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of several Mitogen Activated Protein Kinases in Renal...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Serrano-Oviedo, Leticia, Ortega-Muelas, Marta, García-Cano, Jesús, Valero, María Ll., Cimas, Francisco J., Pascual-Serra, Raquel, Fernandez-Aroca, Diego M., Roche, Olga, Ruiz-Hidalgo, María J., Belandia, Borja, Giménez-Bachs, José M., Salinas, Antonio S., Sanchez-Prieto, Ricardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062059/
https://ncbi.nlm.nih.gov/pubmed/30048489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200878
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