ERK5/BMK1 Is a Novel Target of the Tumor Suppressor VHL: Implication in Clear Cell Renal Carcinoma

Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded through the ubiquitin-proteasome system, in a process...

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Detalhes bibliográficos
Main Authors: Arias-González, Laura, Moreno-Gimeno, Inmaculada, del Campo, Antonio Rubio, Serrano-Oviedo, Leticia, Valero, María Llanos, Esparís-Ogando, Azucena, de la Cruz-Morcillo, Miguel Ángel, Melgar-Rojas, Pedro, García-Cano, Jesús, Cimas, Francisco José, Hidalgo, María José Ruiz, Prado, Alfonso, Callejas-Valera, Juan Luis, Nam-Cha, Syong Hyun, Giménez-Bachs, José Miguel, Salinas-Sánchez, Antonio S, Pandiella, Atanasio, del Peso, Luis, Sánchez-Prieto, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664997/
https://ncbi.nlm.nih.gov/pubmed/23730213
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