The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

OBJECTIVE: ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Grimm, Wesley A, Messer, Jeannette S, Murphy, Stephen F, Nero, Thomas, Lodolce, James P, Weber, Christopher R, Logsdon, Mark F, Bartulis, Sarah, Sylvester, Brooke E, Springer, Amanda, Dougherty, Urszula, Niewold, Timothy B, Kupfer, Sonia S, Ellis, Nathan, Huo, Dezheng, Bissonnette, Marc, Boone, David L
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Colon
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789828/
https://ncbi.nlm.nih.gov/pubmed/25645662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308735
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