Synchronized targeting of Notch and ERBB signaling suppresses melanoma tumor growth through inhibition of Notch1 and ERBB3

Despite significant advances in melanoma therapy, melanoma remains the deadliest form of skin cancer, with a five-year survival of only 15%. Novel treatments are therefore required to address this disease. Notch and ERBB are evolutionarily conserved signaling cascades required for the maintenance of...

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Bibliografiske detaljer
Udgivet i:	J Invest Dermatol
Main Authors:	Zhang, Keman, Wong, Poki, Salvaggio, Christine, Salhi, Amel, Osman, Iman, Bedogni, Barbara
Format:	Artigo
Sprog:	Inglês
Udgivet:	2015
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4789778/ https://ncbi.nlm.nih.gov/pubmed/26967479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2015.11.006
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Synchronized targeting of Notch and ERBB signaling suppresses melanoma tumor growth through inhibition of Notch1 and ERBB3

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