ErbB3/ErbB2 complexes as a therapeutic target in a subset of wild-type BRAF/NRAS cutaneous melanomas

The treatment options remain limited for melanoma patients who are wild-type for both BRAF and NRAS (WT/WT). We demonstrate that a subgroup of WT/WT melanomas display high basal phosphorylation of ErbB3 that is associated with autocrine production of the ErbB3 ligand, neuregulin-1 (NRG1). In WT/WT m...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Capparelli, Claudia, Rosenbaum, Sheera, Berman-Booty, Lisa D., Salhi, Amel, Gaborit, Nadège, Zhan, Tingting, Chervoneva, Inna, Roszik, Jason, Woodman, Scott E., Davies, Michael A., Setiady, Yulius Y., Osman, Iman, Yarden, Yosef, Aplin, Andrew E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558382/
https://ncbi.nlm.nih.gov/pubmed/26206558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2959
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