Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation

Notch1 is an evolutionarily conserved signaling molecule required for stem cell maintenance that is inappropriately reactivated in several cancers. We have previously shown that melanomas reactivate Notch1 and require its function for growth and survival. However, no Notch1-activating mutations have...

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Hlavní autoři: Ma, Jun, Tang, Xiaoying, Wong, Poki, Jacobs, Barbara, Borden, Ernest C., Bedogni, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961669/
https://ncbi.nlm.nih.gov/pubmed/24492617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516039
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