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A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth
The Notch pathway is an evolutionary conserved signaling cascade that has an essential role in melanoblast and melanocyte stem cell homeostasis. Notch signaling is emerging as a key player in melanoma, the most deadly form of skin cancer. In melanoma, Notch1 is inappropriately reactivated and contri...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201386/ https://ncbi.nlm.nih.gov/pubmed/22249266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.606 |
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