Notch1 is an effector of Akt and hypoxia in melanoma development

Melanomas are highly aggressive neoplasms resistant to most conventional therapies. These tumors result from the interaction of altered intracellular tumor suppressors and oncogenes with the microenvironment in which these changes occur. We previously demonstrated that physiologic skin hypoxia contr...

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Bibliographic Details
Main Authors: Bedogni, Barbara, Warneke, James A., Nickoloff, Brian J., Giaccia, Amato J., Powell, Marianne Broome
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567838/
https://ncbi.nlm.nih.gov/pubmed/18924608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36157
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