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Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1

Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that the IDH1 mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and that reprogram...

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Библиографические подробности
Опубликовано в: :Mol Cell Oncol
Главные авторы: Viswanath, Pavithra, Ronen, Sabrina M.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789071/
https://ncbi.nlm.nih.gov/pubmed/26985452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1077922
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