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Static and Dynamic Factors Limit Chromosomal Replication Complexity in Escherichia coli, Avoiding Dangers of Runaway Overreplication

We define chromosomal replication complexity (CRC) as the ratio of the copy number of the most replicated regions to that of unreplicated regions on the same chromosome. Although a typical CRC of eukaryotic or bacterial chromosomes is 2, rapidly growing Escherichia coli cells induce an extra round o...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Khan, Sharik R., Mahaseth, Tulip, Kouzminova, Elena A., Cronan, Glen E., Kuzminov, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788131/
https://ncbi.nlm.nih.gov/pubmed/26801182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.184697
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