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Prompt repair of hydrogen peroxide-induced DNA lesions prevents catastrophic chromosomal fragmentation
Iron-dependent oxidative DNA damage in vivo by hydrogen peroxide (H(2)O(2), HP) induces copious single-strand(ss)-breaks and base modifications. HP also causes infrequent double-strand DNA breaks, whose relationship to the cell killing is unclear. Since hydrogen peroxide only fragments chromosomes i...
Gardado en:
| Publicado en: | DNA Repair (Amst) |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851570/ https://ncbi.nlm.nih.gov/pubmed/27078578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.03.012 |
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