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Prompt repair of hydrogen peroxide-induced DNA lesions prevents catastrophic chromosomal fragmentation

Iron-dependent oxidative DNA damage in vivo by hydrogen peroxide (H(2)O(2), HP) induces copious single-strand(ss)-breaks and base modifications. HP also causes infrequent double-strand DNA breaks, whose relationship to the cell killing is unclear. Since hydrogen peroxide only fragments chromosomes i...

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Publicat a:DNA Repair (Amst)
Autors principals: Mahaseth, Tulip, Kuzminov, Andrei
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851570/
https://ncbi.nlm.nih.gov/pubmed/27078578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.03.012
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