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Cyanide enhances hydrogen peroxide toxicity by recruiting endogenous iron to trigger catastrophic chromosomal fragmentation

Hydrogen peroxide (HP) or cyanide (CN) are bacteriostatic at low-millimolar concentrations for growing Escherichia coli, whereas CN+HP mixture is strongly bactericidal. We show that this synergistic toxicity is associated with catastrophic chromosomal fragmentation. Since CN-alone does not kill at a...

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Publicado en:Mol Microbiol
Autores principales: Mahaseth, Tulip, Kuzminov, Andrei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414041/
https://ncbi.nlm.nih.gov/pubmed/25598241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12938
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