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Chromosome demise in the wake of ligase-deficient replication
Bacterial DNA ligases, NAD(+)-dependent enzymes, are distinct from eukaryotic ATP-dependent ligases, representing promising targets for broad-spectrum antimicrobials. Yet, the chromosomal consequences of ligase-deficient DNA replication, during which Okazaki fragments accumulate, are still unclear....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370103/ https://ncbi.nlm.nih.gov/pubmed/22582878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2012.08076.x |
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