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Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2

Eukaryal translation initiation factor 2B (eIF2B) acts as guanine nucleotide exchange factor (GEF) for eIF2 and forms a central target for pathways regulating global protein synthesis. eIF2B consists of five non-identical subunits (α–ϵ), which assemble into a catalytic subcomplex (γ, ϵ) responsible...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Kuhle, Bernhard, Eulig, Nora K., Ficner, Ralf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787765/
https://ncbi.nlm.nih.gov/pubmed/26384431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv930
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