Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy

The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen tension that leads to aberrant metabolic functions. Metabolic dysfunctions have been documented to play a crucial role in the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Rahman, Md Habibur, Jha, Mithilesh Kumar, Kim, Jong-Heon, Nam, Youngpyo, Lee, Maan Gee, Go, Younghoon, Harris, Robert A., Park, Dong Ho, Kook, Hyun, Lee, In-Kyu, Suk, Kyoungho
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786733/
https://ncbi.nlm.nih.gov/pubmed/26769971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699215
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