Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy

The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen tension that leads to aberrant metabolic functions. Metabolic dysfunctions have been documented to play a crucial role in the...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Rahman, Md Habibur, Jha, Mithilesh Kumar, Kim, Jong-Heon, Nam, Youngpyo, Lee, Maan Gee, Go, Younghoon, Harris, Robert A., Park, Dong Ho, Kook, Hyun, Lee, In-Kyu, Suk, Kyoungho
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786733/
https://ncbi.nlm.nih.gov/pubmed/26769971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699215
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