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mTORC1 Induces Purine Synthesis Through Control of the Mitochondrial Tetrahydrofolate Cycle
In response to growth signals, mTOR complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human cells, thereby influencing the nucleotide pool available for nucleic acid...
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| Publicado en: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786372/ https://ncbi.nlm.nih.gov/pubmed/26912861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad0489 |
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