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mTORC1 Induces Purine Synthesis Through Control of the Mitochondrial Tetrahydrofolate Cycle

In response to growth signals, mTOR complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human cells, thereby influencing the nucleotide pool available for nucleic acid...

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Bibliografische gegevens
Gepubliceerd in:Science
Hoofdauteurs: Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J.H., Asara, John M., Manning, Brendan D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786372/
https://ncbi.nlm.nih.gov/pubmed/26912861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad0489
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