DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic basis underlying drug-induced senescence remains unclear.macroH2A1, a variant of histone H2A, is a marker of senesce...

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Опубликовано в: :Cancer Res
Главные авторы: Borghesan, Michela, Fusilli, Caterina, Rappa, Francesca, Panebianco, Concetta, Rizzo, Giovanni, Oben, Jude A., Mazzoccoli, Gianluigi, Faulkes, Chris, Pata, Illar, Agodi, Antonella, Rezaee, Farhad, Minogue, Shane, Warren, Alessandra, Peterson, Abigail, Sedivy, John M., Douet, Julien, Buschbeck, Marcus, Cappello, Francesco, Mazza, Tommaso, Pazienza, Valerio, Vinciguerra, Manlio
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785885/
https://ncbi.nlm.nih.gov/pubmed/26772755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1336
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