DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic basis underlying drug-induced senescence remains unclear.macroH2A1, a variant of histone H2A, is a marker of senesce...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Borghesan, Michela, Fusilli, Caterina, Rappa, Francesca, Panebianco, Concetta, Rizzo, Giovanni, Oben, Jude A., Mazzoccoli, Gianluigi, Faulkes, Chris, Pata, Illar, Agodi, Antonella, Rezaee, Farhad, Minogue, Shane, Warren, Alessandra, Peterson, Abigail, Sedivy, John M., Douet, Julien, Buschbeck, Marcus, Cappello, Francesco, Mazza, Tommaso, Pazienza, Valerio, Vinciguerra, Manlio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785885/
https://ncbi.nlm.nih.gov/pubmed/26772755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1336
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