DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic basis underlying drug-induced senescence remains unclear.macroH2A1, a variant of histone H2A, is a marker of senesce...

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Pubblicato in:Cancer Res
Autori principali: Borghesan, Michela, Fusilli, Caterina, Rappa, Francesca, Panebianco, Concetta, Rizzo, Giovanni, Oben, Jude A., Mazzoccoli, Gianluigi, Faulkes, Chris, Pata, Illar, Agodi, Antonella, Rezaee, Farhad, Minogue, Shane, Warren, Alessandra, Peterson, Abigail, Sedivy, John M., Douet, Julien, Buschbeck, Marcus, Cappello, Francesco, Mazza, Tommaso, Pazienza, Valerio, Vinciguerra, Manlio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785885/
https://ncbi.nlm.nih.gov/pubmed/26772755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1336
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